McMaster Immunology Research Centre’s Seminar Series Online(MSSOL), Immunology and Infection Program Series, Wednesday, October 27, 2021, 9-10 a.m. ET
Speaker: Neeloffer Mookherjee, Ph.D., CIHR Sex and Gender Science Chair in Circulatory and Respiratory Health, Professor, Departments of Internal Medicine and Immunology, Manitoba Centre for Proteomics & Systems Biology, Rady Faculty of Health Sciences, University of Manitoba, Chair, Women In Science: Development, Outreach & Mentoring (WISDOM) Manitoba
Title: “Dysregulation of host defense by environmental exposures: Immunomodulation to alleviate the pathophysiology”
Environmental exposures such as allergens and air pollution are critical risk factors of respiratory and cardiovascular disease. We have defined changes in the lung proteome in response to inhaled allergens (e.g. house dust mite) and air pollution (using diesel exhaust as a paradigm of traffic-related air pollution), in human and animal exposure models. It is known that exposure to inhaled allergens and air pollution increases susceptibility to pulmonary infections. Our proteomics studies have demonstrated that family of molecules known as cationic host defence peptides with potent antimicrobial functions is dysregulated in the lungs by these environmental exposures. We have further explored strategies to counter these deleterious effects by exogenous administration of synthetic innate defence regulator peptides, derived from natural host defence peptides. This talk will summarize our studies in defining biological pathways and protein networks in the lungs that are altered in response to inhaled environmental exposures, and strategies to counter these effects by immunomodulatory mechanisms mediated by innate defence regulator peptides.
The seminar will be hosted by Dr. Carl Richards, MIRC Director
For more information or the zoom link, please contact MIRC admin.