A new study published in Cell Host and Microbe by Dr. Dawn Bowdish’s group, demonstrates the effect of the aging on the microbiota and how these changes drive intestinal permeability, age-associated inflammation, and decreased macrophage function. The study, co-authored by Netusha Thevaranjan and Alicja Puchta, uses multiple mouse models to show that age-associated inflammation is driven by an aging microbiota, and reducing TNF levels can reverse both age-related microbial changes and inflammation. This has important implications regarding how maintaining a healthy microbiome and reversing age-related microbial changes can help improve our health as we grow older. Read the full story here.

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